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Pilot Results for Psilocybin-Assisted Psychotherapy for Cocaine Use ...
Over a 9-year period, Hendricks and colleagues1 piloted psilocybin-assisted therapy for cocaine use disorder (CUD) among 40 adults. Results supported the treatment for improving cocaine-related outcomes (eg, abstinence and relapse) over 180 days posttreatment. Secondary substance use outcomes or...
Psilocybin - Wikipedia
Psilocybin, also known as 4-phosphoryloxy-N,N-dimethyltryptamine (4-PO-DMT),[a] is a naturally occurring tryptamine alkaloid and investigational drug found in more than 200 species of mushrooms, with hallucinogenic and serotonergic effects.[21][25] Effects include euphoria, changes in perception, a distorted sense of time,[26] and perceived spiritual experiences.PsilocybinINN: PsilocybineSkeletal formula of canonical psilocybinBall-and-stick model of canonical psilocybinClinical dataPronunciation sy-lə-SY-bin, Other namesPsilocybine; Psilocibin; Psylocybin; Psilotsibin; Psilocin phosphate; Psilocin phosphate ester; O-Phosphorylpsilocin; O-Phosphoryl-4-hydroxy-N,N-dimethyltryptamine; 4-Phosphoryloxy-N,N-dimethyltryptamine; 4-PO-DMT; COMP360; COMP-360; CY-39; CY39; PSOP, Psilocybin (USAN US)DependenceliabilityLow[1][2][3][4][5]AddictionliabilityLow[1][6]Routes ofadministration By mouth, intravenous[7] Drug classSerotonergic psychedelic; Hallucinogen; Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist[8]ATC codeNoneLegal statusLegal status AU: S9/S8 (Controlled Drug) BR: Class F2 (Prohibited psychotropics)[9] CA: Schedule III UK: Class A US: Schedule I Pharmacokinetic dataBioavailabilityOral: 52.7 ± 20.4% (as psilocin) (n=3)[10][11][12]Protein binding66%[13]MetabolismLiver, other tissues:[11][10][7][14]• Dephosphorylation (ALPTooltip alkaline phosphatase)• Demethylation and deamination (MAOTooltip monoamine oxidase)• Oxidation (ALDHTooltip aldehyde dehydrogenase)• Glucuronidation (UGTs)Metabolites• Psilocin[11][10][7]• Psilocin-O-glucuronide[10][7]• 4-Hydroxyindole-3-acetaldehyde[10][7]• 4-Hydroxyindole-3-acetic acid (4-HIAA)[10][7]• 4-Hydroxytryptophol[10][7]Onset of actionOral: 0.5–0.8 (range 0.1–1.5) h[15][11]IVTooltip Intravenous injection: immediate[16][17]Elimination half-lifeOral (as psilocin): 2.1–4.7 h (range 1.2–18.6 h)[10][18][19]IVTooltip Intravenous administration (as psilocin): 1.2 h (range 1.8–4.5 h)[10][2]Duration of actionOral: 4–6 h (range 3–12 h)[11][20][21]IVTooltip Intravenous injection: 15–60 min (1–2 mg)[2][12][16][17]ExcretionUrine (mainly as psilocin-O-glucuronide, 2–4% as unchanged psilocin)[10][7][22]Identifiers IUPAC name [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate CAS Number520-52-5 PubChem CID10624DrugBankDB11664ChemSpider10178 UNII2RV7212BP0KEGGD12881 ChEBICHEBI:8614 ChEMBLChEMBL194378 CompTox Dashboard (EPA)DTXSID0048898 ECHA InfoCard100.007.542 Chemical and physical dataFormulaC12H17N2O4PMolar ma...
Management of obsessive-compulsive disorder in adults - The BMJ
psilocybin for OCD to ... As these trials progress, they may broaden the available toolbox for clinicians managing difficult to treat OCD presentations.
Psilocybin and OCD: Interrupting the Loop | OOTW Journal
They are failed attempts to silence a signal that should switch off but does not. For decades, treatment consisted of SSRIs and cognitive-behavioural therapy, ...
