Vetted by NeuralPress's Multi-Agent Verifier for strict factual validity and event relevance. Our compliance engine cross-checks and filters search results to ensure zero false correlations or misleading content.
Primary Sources
Colorectal cancer - Latest research and news | Nature
Related Subjects Latest Research and Reviews Emerging trends in the global burden of colorectal cancer The incidence of colorectal cancer (CRC) has historically been the highest among Western, high-income countries but is now increasing globally beyond these regions. Early-onset CRC (diagnosed before the age of 50 years) has been the main driver of this rise, and risk factors including dietary and lifestyle aspects, the gut microbiota and environmental contaminants have been proposed to underlie these epidemiological trends. The authors of this Review discuss the available evidence on these risk factors, highlighting how the under-representation of non-Western populations in these studies is limiting progress. David J. LeeAparna ParikhAndrew T. Chan News and Comment Did ATOMIC really improve on the standard of care for mismatch repair-deficient colon cancer? The ATOMIC trial has been widely celebrated as providing a positive result. However, when viewed with a lens of critical appraisal that considers issues related to overtreatment, treatment de-escalation, surrogacy, post-trial access to treatment and contributions of component, we argue that ATOMIC should not change clinical practice but rather form the basis for future trials that test de-escalation strategies. Javier-David Benitez-FuentesDeme KarikiosBishal Gyawali A fatty competitor in tumour immunity Adipose tissue and adipocytes have been implicated in promoting tumour progression and hindering anti-tumour immunity. Wang et al. investigated the functional role of tumour-associated visceral adipose tissue in regulating colorectal cancer anti-tumour immunity and immunotherapy efficacy. Gabrielle Brewer When the time is right In a study published in Nature, Lourenço et al. demonstrate that strong oncogenic driver mutations undergo negative selection unless they occur in a permissive tissue context. Daniela Senft
Colorectal cancer - Wikipedia
"Intestinal cancer" redirects here. For cancer of the small intestine, see Small intestine cancer. Colorectal cancerOther namesColon cancerrectal cancerbowel cancerLocation and appearance of two example colorectal tumorsSpecialtyGastroenterology General surgery OncologySymptomsBlood in stoolchange in bowel movementsunintentional weight lossvomitingfatigue[1]CausesLifestyle factors and genetic disorders[2][3]Risk factorsDietobesitysmokinglack of physical activityalcohol use[2][4]Diagnostic methodBiopsy during a sigmoidoscopy or colonoscopy[1]PreventionScreening from age of 45 to 75TreatmentSurgeryradiation therapychemotherapytargeted therapy[5]PrognosisFive-year survival rate 65% (US)[6]Frequency1.9 million (2022)[7]Deaths903,859 (2022)[7] Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). It is the consequence of uncontrolled growth of colon cells that can invade/spread to other parts of the body.[5] Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, abdominal pain and fatigue.[8] Most colorectal cancers are due to lifestyle factors and genetic disorders.[2][3] Risk factors include diet, obesity, smoking, and lack of physical activity.[2] Dietary factors that increase the risk include red meat, processed meat, and alcohol.[2][4] Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis.[2] Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases.[2][3] It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.[2] Colorectal cancer may be diagnosed by obtaining a sample of the colon during a sigmoidoscopy or colonoscopy.[1] This is then followed by medical imaging to determine whether the cancer has spread beyond the colon or is in situ.[5] Screening is effective for preventing and decreasing deaths from colorectal cancer.[9] Screening, by one of several methods, is recommended starting from ages 45 to 75. It was recommended starting at age 50, but it was changed to 45 due to the increasing number of colon cancers.[9][10] During colonoscopy, small polyps may be removed if found.[2] If a large polyp or tumor is found, a biopsy may be performed to check if it is cancerous....
I Was Diagnosed With Stage 4 Cancer at 31. This Mindset ... - Newsweek
I Was Diagnosed With Stage 4 Cancer at 31. This Mindset Shift Turned My Life Around Published Apr 25, 2026 at 07:00 AM EDT
Announcing the Lancet Commission on colorectal cancer: addressing the ...
Colorectal cancer is a major global health burden, accounting for about 10% of all cancer incidence and nearly 1 million deaths worldwide between 2020 and 2022.1,2 Projections indicate that this burden will increase substantially in the coming decades, reaching more than 3·2 million new cases and 1·6 million deaths annually by 2040.3 The epidemiological landscape of colorectal cancer is ...
